Top Terbaru 16+ Spop Motif

Top Terbaru 16+ Spop Motif

Spop Motif

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The emerging role of SPOP protein in
04 01 2022 This domain specifically recognized short linear motifs of substrates that serve as the specific SPOP binding SB motifs In turn the substrate proteins require the existence of a prerequisite SB 5 residue motif S S T S T nonpolar polar amino acid termed the SPOP binding consensus SBC Moreover the BTB domain is primarily involved in SPOP dimerization as well as Cul 3 binding

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Mutated SPOP E3 ligase promotes 17HSD4
SPOP bound a functional substrate binding consensus SBC motif 315RATST319 in 17HSD4 and promoted non degradable K27 and K29 linked poly ubiquitination of 17HSD4 The effect of SPOP was antagonized by serum and glucocorticoid kinase 3 SGK3 mediated phosphorylation of serine 318 S318 in the SBC and S318 phosphorylation dependent binding of SKP2 E3 ligase and subsequent K48 linked poly ubiquitination and proteasomal degradation of 17HSD4 PCa associated SPOP

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Prostate Cancer associated SPOP mutations
26 11 2022 The SPOP binding consensus motif in Caprin1 is required for SPOP mediated Caprin1 degradation and ubiquitination Previous studies have reported that one or several SPOP binding consensus SBC motifs are present in SPOP substrates We sought to determine the protein sequence of Caprin1 responsible for SPOP binding To this end we first deduced the minimal interacting region

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Intrinsically disordered substrates dictate SPOP
Speckle type POZ protein SPOP is a ubiquitin ligase adaptor that binds substrate proteins and facilitates their proteasomal degradation Most SPOP substrates present multiple SPOP binding motifs and undergo liquid liquid phase separation with SPOP Pancreatic and duodenal homeobox 1 Pdx1 an insulin transcription factor is downregulated by interaction with SPOP Unlike other substrates however Pdx1 was reported to have just one SPOP binding SB motif